3-Hydroxyphencyclidine (3-HO-PCP) for Research

Introduction & Scientific Overview

3-Hydroxyphencyclidine, known chemically as 1-[1-(3-hydroxyphenyl)cyclohexyl]piperidine, is a dissociative substance from the arylcyclohexylamine class related to phencyclidine (PCP). It acts as an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor with significantly higher affinity relative to PCP. The compound also displays interactions with μ-opioid, κ-opioid, and sigma receptors, distinguishing its pharmacological profile.

Initially synthesized in the 1980s, 3-HO-PCP has been a subject of research interest particularly for understanding NMDA receptor antagonism and opioid receptor binding. Unlike therapeutic claims, its primary relevance remains in research settings exploring receptor mechanism and ligand specificity.

Chemical Specifications

Potential Research Applications

3-HO-PCP is employed in vitro for receptor binding studies to investigate NMDA receptor antagonism and opioid receptor pharmacology. It serves as an important compound in molecular pharmacological research examining structure-activity relationships within arylcyclohexylamine dissociatives.

Researchers utilize 3-HO-PCP for exploring receptor-ligand interactions, elucidating mechanisms at the NMDA ion channel, and comparative binding affinity studies, providing valuable insights into dissociative anesthetic pharmacodynamics.

Quality Guarantee & Handling

Each batch of 3-HO-PCP powder is rigorously tested and verified by HPLC to exceed 99% purity. A batch-specific Certificate of Analysis (CoA) ensures quality control and traceability.

Safe laboratory practice mandates the use of personal protective equipment (PPE), including gloves and lab coats, during handling. Avoid inhalation, ingestion, or skin contact.

INTENDED USE & WARNING:
This product is strictly for qualified laboratory research use only. It is not intended for human or animal consumption or therapeutic use. The buyer assumes responsibility for compliance with local regulations and safe handling procedures. Confirmed legal age (over 18 years) is required for purchase.

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This summary provides a scientifically focused, compliant profile for 3-HO-PCP powder to support safe and effective research applications in pharmacology and receptor studies.